A comprehensive portrait of cilia and ciliopathies from a CRISPR-based screen for Hedgehog signaling
نویسندگان
چکیده
1. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511 2. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 3. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 4. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 6. Co-first author
منابع مشابه
Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant
Sonic hedgehog plays an essential role in maintaining hepatoblasts in a proliferative non-differentiating state during embryogenesis. Transduction of the Hedgehog signaling pathway is dependent on the presence of functional primary cilia and hepatoblasts, therefore, must require primary cilia for normal function. In congenital syndromes in which cilia are absent or non-functional (ciliopathies)...
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